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BD Biosciences Cell Signaling Technology InvivoGen Jackson ImmunoResearch Laboratories Enzo Life Sciences Axxora Adipogen VWR Amsbio PerkinElmer Thermo Scientific Berthold DS Sigma Aldrich Millipore

Program (Up-dated: January 19th, 2010)

Wednesday January 27th, 2010
Thursday January 28th, 2010
Friday January 29th, 2010
Saturday January 30th, 2010

Wednesday January 27th, 2010

8h00 - 19h00: Registration
Keynote session:
Chair: Marc Diederich (LBMCC, Luxembourg)
9h30 - 10h30 Jurg Tschopp (University of Lausanne, Lausanne, Switzerland):
The inflammasomes: Guardians of our body
10h30 - 11h00 Coffee break
Session 1: Regulation of cell signaling pathways I
Chair: Young-Joon Surh (Seoul National University, Korea)
11h00 - 11h30 Young-Joon Surh (Seoul National University, Korea):
Redox regulation of pro-inflammatory and anti-inflammatory signaling
11h30 - 12h00 Massimo Locati (Fondazione Humanitas per la Ricerca, Rozzano, Italy):
Signalling and adaptive responses via atypical chemokine receptor D6
12h00 - 12h30 Matthias Gaestel (Hannover Medical School, Germany):
The role of MAPKAP kinases MK2 and MK3 in inflammation and beyond
12h30 - 13h00 Thad Stappenbeck (Washington University, St Louis, USA):
Role of epithelial growth factors in the maintenance of colonic homeostasis
13h00 - 16h00 Lunch, workshops and posters
Workshops Posters
14h00 - 15h00: Becton Dickinson
15h00 - 16h00: Promega 		14h00 - 16h00: Poster session
(free viewing)
Session 2: Regulation of cell signaling pathways II
Chair: Hye-Kyung Na (Sungshin Women's University, Seoul, Korea)
16h00 - 16h30 Veronique Baud (Institut Cochin-INSERM U567, Paris, France):
Novel roles of the alternative NF-kappaB pathway
16h30 - 17h00 Rudi Beyaert (Ghent University - Department for Biomedical Molecular Biology, Belgium):
The NF-κB inhibitor A20 as a peacekeeper in inflammation and immunity
17h00 - 17h30 Hye-Kyung Na (Sungshin Women's University, Seoul, Korea):
Role of IkappaB kinase in 4-Hydroxyestradiol-induced migration and transformation of human mammary epithelial cells
17h30 - 18h00 Wouter de Jonge (Academic Medical Center, Amsterdam, The Netherlands):
Acetylcholine modulates innate immune cell activation via Jak/Stat and NF-κB signaling pathways
18h00 - 18h20 Roberto Gambari (Ferrara University, Italy):
Decoy PNA-DNA-PNA chimeras targeting NF-κB transcription factors inhibit IL-8 gene expression in cystic fibrosis IB3-1 infected with Pseudomonas aeruginosa
18h20 - 18h40 Emmanuel Dejardin (GIGA-Research, University of Liège, Belgium):
TNFL-Induced p100 processing (TIPP) relies on the internalization of the cognate TNFR
18h40 - 19h00 Hyeyoung Kim (Yonsei University, Seoul, Korea):
Effect of lipid-associated membrane proteins from Mycoplasma pneumoniae on IL-8 expression in glutamine-deficient human alveolar epithelial A549 cells
19h00 - 19h30 Official talks and inauguration
19h30 - 20h30 Reception offered by the City of Luxembourg
20h30 - 21h00 Shuttles leave to the hotels from the meeting center
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Thursday January 28th, 2010

Shuttle bus from the hotels to the meeting center (see map for details)
8h00 - 19h00: Registration
Session 3: Inflammatory mediators
Chair: Bharat B. Aggarwal (M. D. Anderson Cancer Center, USA)
8h30 - 9h00 Bharat B. Aggarwal (The University of Texas M. D. Anderson Cancer Center, USA):
Targeting Inflammatory Pathways for Prevention and Treatment of Cancer
9h00 - 9h30 Sankar Ghosh (Columbia University, New York, USA):
Regulation of inflammatory signaling by TNF receptor
9h30 - 10h00 Edward A. Dennis (University of California, USA):
TLR4 Initiated Phospholipase A2 Signaling via Pro- and Anti- Inflammatory Eicosanoids
10h00 - 10h30 Zigang Dong (Homel Institute, University of Minnesota, USA):
Signal transduction in Solar UV-induced skin inflation and cancer
10h30 - 11h00 Coffee break
Session 4: Epigenetic and transcriptional control in inflammatory diseases
Chair: Jonathan Turner (Institute of Immunology, Luxembourg)
11h00 - 11h30 Ajay Goel (Baylor University Medical Center, Dallas, USA):
Epigenetic Changes by Dietary Agents
11h30 - 12h00 Guy Haegeman (University of Ghent, Belgium):
Impact of chromatin on inflammatory gene expression
12h00 - 12h20 Jonathan Turner (Institute of Immunology, Luxembourg):
Methylation of the (anti-inflammatory) glucocorticoid receptor promoter
12h20 - 12h40 Oliver H. Krämer (Friedrich-Schiller-University Jena, Germany):
Crosstalk between stimulated NF-κB and the tumor suppressor p53
12h40 - 13h00 Alexander Remels (Maastricht University, the Netherlands):
TNF-α impairs regulation of skeletal muscle oxidative capacity through activation of NF-κB
Workshops Posters
13h00 - 14h00: IBA
14h00 - 15h00: Polyplus - Transfection
15h00 - 16h00: AMS Biotechnology 		14h00 - 16h00: Poster session
(all posters with even numbers: 2, 4, 6)
Session 5: Virus infections and innate immunity
Chair: Jacques Piette (Université de Liège, Belgium)
16h00 - 16h30 Jacques Piette (Université de Liège, Belgium):
Varicella-zoster virus interferes with innate immune signaling pathways
16h30 - 17h00 Andrew Bowie (Trinity College Dublin, Ireland):
Novel regulators of pattern recognition receptor signaling
17h00 - 17h30 Christian Münz (University of Zürich, Switzerland):
Priming of protective and tumor specific T cell responses in mice with human immune system component
17h30 - 18h00 Johannes Bode (University of Düsseldorf, Germany):
Role of the interplay of MK2 and MK3 for IRF3 dependent effects of LPS
18h00 - 18h30 Yong Sang Song (Seoul National University, Korea):
Human papillomavirus 16 E5 oncoprotein as an inducer of inflammatory cell signaling
18h30 - 19h00 Stephen J. Galli (Stanford University, USA):
Mast cells as negative regulators of innate and adaptive immune responses
19h00 Shuttles leave to the hotels from the meeting center
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Friday January 29th, 2010

Shuttle bus from the hotels to the meeting center (see map for details)
8h00 - 19h00: Registration
Session 6: Chronic Inflammatory pathologies - Part I
Chair: Kapil Mehta (M.D. Anderson Cancer Center, Houston, USA)
8h30 - 9h00 Seth Masters (National Institutes of Arthritis and Musculoskeletal and Skin Diseases, USA):
New additions and mechanistic insight into the spectrum of autoinflammatory disease
9h00 - 9h30 Decio L. Eizirik (Université Libre de Bruxelles, Belgium):
Signal transduction of inflammation-mediated beta-cell apoptosis in type 1 diabetes
9h30 - 10h00 Sushovan Guha (M.D. Anderson Cancer Center, Houston, USA):
G protein-coupled receptor mediated signaling pathways in pancreatic cancer
10h00 - 10h30 Kapil Mehta (M.D. Anderson Cancer Center, Houston, USA):
Tissue transglutaminase (TG2): a proinflammatory protein promotes cell survival and invasive signaling in cancer cells
10h30 - 11h00 Coffee break
Session 7: Chronic Inflammatory pathologies - Part II
Chair: Seth Masters (National Institutes of Arthritis and Musculoskeletal and Skin Diseases, USA)
11h00 - 11h30 Sunil Krishnan (M.D. Anderson Cancer Center, Houston, USA):
Targeting Inflammatory Pathways for Radiosensitization of Cancer
11h30 - 11h50 Franck Morceau (LBMCC, Luxembourg):
TNF alpha and anemia
11h50 - 12h10 Malgorzata Rogalinska (Medical University of Vienna, Austria):
Usefulness of differential scanning calorimetry for evaluation of treatment efficacy and development of personalized therapy of chronic lymphocytic leukemia
12h10 - 12h30 Jenny E. Gumperz (University of Wisconsin School of Medicine and Public Health, USA):
Recognition of Lyso-phosphatidylcholine by Human Natural Killer T Lymphocytes
12h30 - 12h50 George Hajishengallis (University of Louisville, USA):
Complement pathways involved in periodontal inflammation
12h50 - 13h10 Salahaddin Mahmudi-Azer (University of Calgary, Alberta, Canada):
Redefining Eosinophil Crystalloid Granules as a Potential New Functional Unit in Extracellular Inflammatory Events
13h10 - 13h30 Alfonso Pompella (Dept. of Experimental Pathology, University of Pisa, Italy):
A safe procedure® for measurment of S-nitrosoglutathione, the central metabolite in S-nitrosothiols formation and bioactivity
Workshops Posters
14h00 - 15h00: Bio-Rad
15h00 - 16h00: GE Healthcare 		14h00 - 16h00: Poster session
(all posters with odd numbers: 1, 3, 5)
Session 8: Regulation of cell signaling pathways III
Chair: Ivana Scovassi (IGM-CNR, Pavia, Italy)
16h00 - 16h30 Varsha Gandhi (M. D. Anderson Cancer Center, Houston, TX, USA):
Targeting Bcl-2 Family Survival Proteins
16h30 - 17h00 Peter Friedl (Radboud University Nijmegen Medical Centre, The Netherlands):
Killing of cancer cells by CTL
17h00 - 17h30 Ivana Scovassi (IGM-CNR, Pavia, Italy):
PARP inhibitors: new tools to protect from inflammation
17h30 - 17h50 Claudia Cerella (LBMCC, Luxembourg):
Anti-apoptotic effect of COX2 inhibitors
17h50 - 18h10 Alicia Torriglia (INSERM U 872, Paris, France):
Glucocorticoides induce cell death in the retina
18h10 - 18h30 Béatrice Charreau (Université de Nantes, France):
Dysregulates Notch Signaling in Endothelial Cells: Implication of Notch2 and Notch4 to endothelial dysfunction
18h30 - 18h50 Thomas Luft (German Cancer Research Center, Heidelberg, Germany):
The second signal in antigen-presenting cells: Complementary JAK1 directs pro- and anti-inflammatory cytokine production induced by CD40L
18h50 - 19h10 Iris Behrmann (Life Sciences Research Unit, University of Luxembourg):
Hypoxia-inducible factor 1a is upregulated by Oncostatin M and participates in Oncostatin M signalling
19h15 Shuttles leave to the hotels from the meeting center
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Saturday January 30th, 2010

Shuttle bus from the hotels to the meeting center (see map for details)
8h00 - 13h00: Registration
Session 9: Natural compounds and inflammation cell signalling I
Chair: Norbert Latruffe (INSERM U 866; University of Burgundy, France)
8h30 - 9h00 Lina Ghibelli (University of Rome Tor Vergata, Italy):
Novel signaling pathways induced by melatonin in leukocytes: inflammatory implications and pharmacological perspectives
9h00 - 9h30 De-Xing Hou (Kagoshima University, Japan):
Flavonoids as anti-inflammatory compounds: targeting signaling and molecules
9h30 - 9h50 Norbert Latruffe (INSERM U 866; University of Burgundy, France):
Responses of cell targets to resveratrol; involvement of common or separated mechanisms?
9h50 - 10h10 Francesco Peri (University of Milano Bicocca, Italy):
A chemical genetic approach to the study of the TLR4 pathway: new chemical entities targeting selectively the CD14 and MD-2 receptors
10h10 - 10h30 Flavia Radogna (University of Rome Tor Vergata, Italy):
Interference between nitric oxide synthase and lipoxygenase pathways leads to reciprocal abrogation of the effects of melatonin and magnetic fields in leukocytes
10h30 - 11h00 Coffee break
Session 8: Natural compounds and inflammation cell signalling II
Chair: Józefa Wesierska-Gadek (Medical University of Vienna, Austria)
11h00 - 11h20 Assam El-Osta (Baker IDI Heart and Diabetes Institute, Melbourne, Australia):
The legacy of hyperglycemia is associated with persistent gene-activating epigenetic marks on the NF-κB-p65 gene
11h20 - 11h40 Marc Schumacher (LBMCC, Luxembourg):
Marine compounds as anti-inflammatory and anti-cancer agents
11h40 - 12h00 Veera R. Konda (KinDex Therapeutics, USA):
Substituted 1,3-cyclopentadiones analogues differentially inhibit inflammation in vitro and collagen-induced arthritis in mice
12h00 - 12h20 Józefa Wesierska-Gadek (Medical University of Vienna, Austria):
Impact of selective CDK inhibitors on functional status of cellular factors promoting survival of cancer cells
12h20 - 12h40 Dietmar Fuchs University (Clinics, Innsbruck, Austria):
In vitro testing for anti-inflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donors
12h40 - 13h00 Stephan Immenschuh (Justus-Liebig-University Giessen, Giessen, Germany):
Inhibition and genetic deficiency of p38 MAPK induces the anti-inflammatory heme oxygenase-1 gene via the redox-regulated transcription factor Nrf2 in macrophages
13h00 - 14h00 Lunch and end of the meeting
14h00 Shuttles leave to the hotels from the meeting center
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